Sciatic neuropathy following endovascular treatment of a limb vascular malformation
© Ney et al. 2006
Received: 04 July 2006
Accepted: 15 December 2006
Published: 15 December 2006
Endovascular therapy for vascular malformations is one of the treatment options for limb vascular malformations.
A patient with a vascular malformation of the hip developed ipsilateral leg weakness immediately after endovascular embolization and sclerotherapy. Clinical and electrodiagnostic findings later confirmed an incomplete sciatic neuropathy.
We propose that endovascular treatment compromised the patient's sciatic nerve either through direct neurotoxicity of the sclerosing agent or ischemic injury.
Vascular malformations of the limbs can present with a variety of symptoms. Diagnostic investigations uncover a range of anatomical complexity. Tools in the management of these lesions include direct surgical intervention, percutaneous sclerotherapy, and catheter-guided angiographic approaches.  Endovascular sclerotherapy is a more selective method aimed at reducing blood flow within the vascular malformation. Identification of feeding vessels to muscles and nerves are essential in reducing the risk of vascular compromise to these structures. We report a patient with a large arteriovenous malformation (AVM) of the hip undergoing selective endovascular embolosclerotherapy who developed a post-procedure sciatic neuropathy.
Immediately following the procedure, the patient had new complaints of right leg weakness. Physical examination revealed complete inability to dorsiflex or invert the right foot. She had 4/5 MRC scale strength of plantar flexion, foot inversion, and knee flexion, with preservation of strength in hip girdle muscles and knee extensors. Her deep tendon reflexes were 2/4 throughout with the exception of a 1/4 right ankle jerk. She was anesthetic on her right lateral leg. Subsequent MRI of her lumbar spine and CT of her abdomen and pelvis failed to disclose any acute pathological process. Six weeks later, a nerve conduction study showed absent right superficial peroneal and sural sensory responses, and absent peroneal (recording from the extensor digitorum brevis) and tibial (recording from the abductor hallucis) motor responses. Needle electromyography (EMG) demonstrated muscle membrane instability, manifested by fibrillation potential and positive sharp waves in the right tibialis anterior, medial gastrocnemius, and semitendinosus. No motor unit potentials (MUPs) were observed in the right tibialis anterior. Small, polyphasic MUPs with decreased recruitment were noted in the semitendinosus and gastocnemius. Needle EMG of the gluteus medius and lumbar paraspinal region was normal.
At the time of electrodiagnosis, she had significant atrophy in her right calf, anterior leg and hamstring muscles. Based on the clinical and electrodiagnostic examinations, she was diagnosed with a severe, but incomplete lesion of the right sciatic nerve. Magnetic resonance neurography was unavailable at our institution. Despite vigorous physical therapy, she had not recovered strength since the initial post-endovascular procedure examination. She had not undergone any subsequent nerve repair procedures at the time of this writing.
Embolosclerotherapy is recommended in isolation or as part of a multi-staged approach for treatment of appendicular vascular malformations. Where the vascular malformation is deep with extensive muscle or bony involvement, embolosclerotherapy is preferred to surgical treatments which may leave the patient with greater disability.  Ethanol or N-butyl cyanoacrylate are the sclerosing agents most often utilized. Absolute ethanol is toxic to vascular endothelium, inducing thrombosis in affected vessels.  Delivery of the agent to the nidus of the lesion is essential in reducing systemic side effects, such as pulmonary hypertension.  Catheter-guided techniques are recommended for arteriovenous malformations, whereas percutaneous sclerotherapy is sufficient for venous malformations.  Success as defined by reduction in the size of the vascular malformation and diminished associated symptoms has been reported in up to 94.7% of sessions in percutaneous and catheter-guided techniques followed for an average of 10.6 months. 
Ethanol sclerotherapy may damage peripheral nerves either through direct nerve toxicity or ischemia.  Lee, et al  reported a series of eighty-seven patients who underwent a total of 399 sessions of percutaneous ethanol sclerotherapy. Five nerve palsies were reported; three facial and two peroneal. A mechanism of injury was not postulated.
Reports of catheter-guided endovascular treatments complicated by nerve injury are scant. Liang, et al reported recurrent laryngeal nerve injury resulting in vocal cord paralysis after embolization of patent ductus arteriosus in three infants.  Quinn, et al, published a small series of patients who underwent catheter-guided cisplatin chemotherapy for pelvic cancers that developed femoral and sciatic nerve lesions . Stent-graft of an abdominal aortic aneurysm with embolization of iliac arteries was complicated by lower extremity weakness and fecal incontinence in one patient .
We contend that our patient's nerve injury was the result of ischemia or toxicity to the sciatic nerve. The acuity and severity of the lesion are consistent with either of these pathophysiologies. The sciatic nerve is supplied by vessels ultimately derived from the internal iliac artery. The inferior gluteal artery arises from the anterior division of the internal iliac, descending in the pelvis to give off the sciatic artery. This small vessel maintains the sciatic nerve blood supply through a network of vaso nervorum. Collateral vessels from the iliolumbar, lateral sacral, obturator, and internal pudendal arteries contribute to the vascular supply of the region as well.  Ischemia resulting in nerve injury would involve the inferior gluteal artery primarily, with secondary compromise of other anastamotic vessels.
Our patient had distal coil placement and a neurotoxic vascular sclerosing agent infused into her right anterior internal iliac artery, causing ischemia to the affected vascular territory, including the sciatic nerve. Her three prior infusions and coil placements may have prevented collateral blood flow. Although limb vasculature malformations can cause local muscle necrosis,  we found nerve conduction and electromyographic abnormalities in a sciatic nerve distribution far distal to her lesion. The acute onset of her weakness renders a pre-existing sciatic neuropathy unlikely.
Embolosclerotherapy for limb vascular malformations remains a valuable treatment for a difficult condition. Awareness of the relationship of the vascular malformation and its blood supply to nervous structures may prevent similar neurologic complications of this procedure in the future.
The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Department of the Army or the Department of Defense.
magnetic resonance imaging
medical research council
- Lee BB, Bergan JJ: Advanced management of congenital vascular malformations: a multidisciplinary approach. Cardiovasc Surg 2002, 10:523–33.View ArticlePubMedGoogle Scholar
- Yakes WF, Haas DK, Parker SH, Gibson MD, Hopper KD, Mulligan JS, Pevsner PH, Johns JC Jr, Carter TE: Symptomatic vascular malformations: ethanol embolotherapy. Radiology 1989, 170:1059–66.PubMedGoogle Scholar
- Yakes WF, Pevsner P, Reed M, Donohue HJ, Ghaed N: Serial embolizations of an extremity arteriovenous malformation with alcohol via direct percutaneous puncture. AJR Am J Roentgenol 1986, 146:1038–40.PubMedGoogle Scholar
- Weber J: Embolizing materials and catheter techniques for angiotherapeutic management of AVM. In Vascular Malformations. Edited by: Belov ST, Loose DA, Weber J. Reinbek: Einhorn-Presse Verlag GmbH; 1989:252–60.Google Scholar
- Lee BB, Do YS, Byun HS, Choo IW, Kim DI, Huh SH: Advanced management of venous malformation with ethanol sclerotherapy: mid-term results. J Vasc Surg 2003, 37:533–8.View ArticlePubMedGoogle Scholar
- Liang CD, Ko SF, Huang SC, Huang CF, Niu CK: Vocal cord paralysis after transcatheter coil embolization of patent ductus arteriosus. Am Heart J 2003, 146:367–71.View ArticlePubMedGoogle Scholar
- Quinn SF, Frau DM, Saff GN, Kavanagh J, Roberts W, Cavanagh D, Clark RA: Neurologic complications of pelvic intraarterial chemoembolization performed with collagen material and cisplatin. Radiology 1988, 167:55–7.PubMedGoogle Scholar
- Kwok PC, Chung TK, Chong LC, Chan SC, Wong WK, Chan MK, Chu WS: Neurologic injury after endovascular stent-graft and bilateral internal iliac artery embolization for infrarenal abdominal aortic aneurysm. J Vasc Interv Radiol 2001, 12:761–3.View ArticlePubMedGoogle Scholar
- Breugem CC, Maas M, van der Horst CM: Magnetic resonance imaging findings of vascular malformations of the lower extremity. Plast Reconstr Surg 2001, 108:878–84.View ArticlePubMedGoogle Scholar
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.