Figure 1
From: GAP-43 expression correlates with spinal motoneuron regeneration following root avulsion
Representative photomicrographs showing the expression GAP-43 in avulsed motoneurons in the neonatal and adult rats. No GAP-43-IR was detected in ventral horn of the lesion side in neonatal at 3 days post-injury (B), which was comparable to the age-matched normal control (A). B1 is the enlargement of the square area in the ventral horn of image B showing negative GAP-43-IR of motoneurons (arrows). In contrast, GAP-43-IR was induced in many avulsed motoneurons at 14 days post-injury in the adult animals (D) compared with the adult normal control (C). D1 is the enlargement of the square area in the ventral horn of image D showing positive GAP-43-IR of motoneurons (arrows). Scale bar = 400 μm in A-D, 100 μm in B1 and D1.