Skip to main content

Table 1 Effect of tacrolimus on I/R induced changes in serum nitrate and MDA level

From: Pharmacological evaluation of tacrolimus (FK-506) on ischemia reperfusion induced vasculatic neuropathic pain in rats

Nitrate level (μmol/l)

Groups

0 day

4th day

8th day

12th day

16th day

 

Normal

19.24 ± 0.31

19.91 ± 0.28

19.58 ± 0.42

19. 73 ± 0.34

19.92 ± 0.49

 

Sham

20. 79 ± 0.39

19.57 ± 0.36

19.87 ± 0.47

19.62 ± 0.32

19.35 ± 0.27

 

I/R

20.16 ± 0.26

31.43 ± 1.12a

36.27 ± 1.08a

31.27 ± 0.79a

29.82 ± 0. 74a

 

Vehicle

20.36 ± 0.39

31.26 ± 1.13a

38.16 ± 1.09a

32.53 ± 0.83a

28.93 ± 0.59a

 

Tacrolimus (1)

20.97 ± 0.28

36.67 ± 1.38a

42.94 ± 1.46a

37.39 ± 0.83a

34.69 ± 1.25a

 

Tacrolimus (2)

20.62 ± 0.64

43.78 ± 0.64b

49.38 ± 0.46b

44.67 ± 0.46b

41.67 ± 0.32b

 

Tacrolimus (3)

20.09 ± 0.42

49.59 ± 0.54b

57.35 ± 0.36b

54.56 ± 0.78b

51. 74 ± 0.34b

MDA level (nmol/l)

Normal

0.81 ± 0.32

0.83 ± 0.46

0. 79 ± 0.31

0.82 ± 0.36

0.83 ± 0.43

 

Sham

0.82 ± 0.46

0.81 ± 0.32

0.83 ± 0.31

0.81 ± 0.34

0.85 ± 0.39

 

I/R

0.74 ± 0.39

18.94 ± 1.74a

24.54 ± 1.56a

18.31 ± 1.58a

16.42 ± 2.23a

 

Vehicle

0.86 ± 0.23

18.61 ± 1.34a

25.59 ± 1.61a

17.39 ± 1.57a

17.14 ± 2.01a

 

Tacrolimus (1)

0.82 ± 0.38

26.43 ± 1.58a

33.43 ± 1.67a

28.81 ± 1.58a

26. 74 ± 1.32a

 

Tacrolimus (2)

0.84 ± 0.36

40.36 ± 1.34b

44.61 ± 1.25b

37.67 ± 1.46b

34.38 ± 1.52b

 

Tacrolimus (3)

0.81 ± 0.29

49.71 ± 1.45b

56.36 ± 1.54b

49.69 ± 1.39b

46.41 ± 1.23b

  1. Data were expressed as mean ± S.E.M. for each group. a = P < 0.05 vs sham control group, b = P < 0.05 vs ischemia control group.