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Table 2 Effect of tacrolimus on I/R induced changes in tissue biomarker level

From: Pharmacological evaluation of tacrolimus (FK-506) on ischemia reperfusion induced vasculatic neuropathic pain in rats

Groups

Reduced Glutathione (μg/mg of protein)

MPO Activity

(U/min/mg of protein)

Total Calcium

(ppm/mg of protein)

Normal

72.64 ± 2.91

11.32 ± 1.56

3.49 ± 1.04

Sham

71.31 ± 2.47

12.64 ± 1.37

3.59 ± 0.83

I/R

39.25 ± 1.67a

134.01 ± 3.91a

34.61 ± 1.93a

Vehicle

40.54 ± 1.92a

138.43 ± 3.51a

35.19 ± 1.64a

Tacrolimus (1)

46.47 ± 2.65a

126.32 ± 1.47a

31.69 ± 0.57a

Tacrolimus (2)

63.35 ± 1.69b

62.79 ± 2.63b

14.41 ± 2.61b

Tacrolimus (3)

68.41 ± 1.83b

41.84 ± 3.92b

9.16 ± 1.92b

  1. Data were expressed as mean ± S.E.M. for each group.
  2. a = P < 0.05 vs sham control group,
  3. b = P < 0.05 vs ischemia control group.