Table 2 Effect of Ocimum sanctum and its saponin rich fraction on thio-barbituric acid reactive substances, superoxide anion content and total calcium in vincristine-induced neuropathic pain.

Normal Control

-

5.17 ± 0.23

5.97 ± 0.26

0.15 ± 0.02

4.97 ± 0.21

Vincristine Control

-

5.36 ± 0.13

8.28 ± 0.24^a

0.79 ± 0.05^a

32.20 ± 0.18^a

Vehicle in Vincristine Control

-

5.29 ± 0.17

8.24 ± 0.22^a

0.81 ± 0.03^a

32.02 ± 0.16 ^a

Ocimum sanctum per se

200 mg/kg

5.21 ± 0.15

6.00 ± 0.28

0.16 ± 0.01

5.09 ± 0.15

Saponin rich fraction per se

200 mg/kg

5.30 ± 0.14

6.06 ± 0.24

0.14 ± 0.02

4.92 ± 0.17

Ocimum sanctum in vincristine control

100 mg/kg

5.33 ± 0.22

7.56 ± 0.16^{a, b}

0.56 ± 0.02^{a, b}

29.5 ± 0.18^{a, b}

Ocimum sanctum in vincristine control

200 mg/kg

5.26 ± 0.16

7.52 ± 0.15^{a, b}

0.54 ± 0.03^{a, b}

29.8 ± 0.20^{a, b}

Saponin rich fraction in vincristine control

100 mg/kg

5.35 ± 0.13

6.90 ± 0.19^{a, b, c}

0.38 ± 0.04^{a, b, c}

21.1 ± 0.19^{a, b, c}

Saponin rich fraction in vincristine control

200 mg/kg

5.29 ± 0.14

6.28 ± 0.21^{a, b, c, d}

0.25 ± 0.02^{a, b, c, d}

12.2 ± 0.13^{a, b, c, d}