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Table 2 Effect of Ocimum sanctum and its saponin rich fraction on thio-barbituric acid reactive substances, superoxide anion content and total calcium in vincristine-induced neuropathic pain.

From: Exploring the potential effect of Ocimum sanctum in vincristine-induced neuropathic pain in rats

Groups Doses Total Protein
(mg/g of tissue)
TBARS
(nmol/mg of protein)
Superoxide Anion Content
(pmol/min/mg of protein)
Total Calcium
(ppm/mg of protein)
Normal Control - 5.17 ± 0.23 5.97 ± 0.26 0.15 ± 0.02 4.97 ± 0.21
Vincristine Control - 5.36 ± 0.13 8.28 ± 0.24a 0.79 ± 0.05a 32.20 ± 0.18a
Vehicle in Vincristine Control - 5.29 ± 0.17 8.24 ± 0.22a 0.81 ± 0.03a 32.02 ± 0.16 a
Ocimum sanctum per se 200 mg/kg 5.21 ± 0.15 6.00 ± 0.28 0.16 ± 0.01 5.09 ± 0.15
Saponin rich fraction per se 200 mg/kg 5.30 ± 0.14 6.06 ± 0.24 0.14 ± 0.02 4.92 ± 0.17
Ocimum sanctum in vincristine control 100 mg/kg 5.33 ± 0.22 7.56 ± 0.16a, b 0.56 ± 0.02a, b 29.5 ± 0.18a, b
Ocimum sanctum in vincristine control 200 mg/kg 5.26 ± 0.16 7.52 ± 0.15a, b 0.54 ± 0.03a, b 29.8 ± 0.20a, b
Saponin rich fraction in vincristine control 100 mg/kg 5.35 ± 0.13 6.90 ± 0.19a, b, c 0.38 ± 0.04a, b, c 21.1 ± 0.19a, b, c
Saponin rich fraction in vincristine control 200 mg/kg 5.29 ± 0.14 6.28 ± 0.21a, b, c, d 0.25 ± 0.02a, b, c, d 12.2 ± 0.13a, b, c, d
  1. Data were expressed as mean ± S.E.M., n = 6 rats per group a = p < 0.05 Vs normal control group, b = p < 0.05 Vs vincristine control group, c = p < 0.05 Vs Ocimum sanctum100 and 200 mg/kg group, d = p < 0.05 Vs saponin rich fraction 100 mg/kg group.